After a bank heist, brothers Richie and Seth Gecko plan to head to Mexico to evade arrest. At a motel, Richie kills their hostage and their journey hits a hard spot, but, just when things could have gotten worse, the Fuller family shows up. Seth takes them hostage and the five successfully cross the border. The five pull to a bar called "The Titty Twister", where Seth will meet his handler in the morning. When moon strikes, the stripper and workers turn into vampires and the survivors must soon fight for their lives.