Serafini started his career with a role in the short film Smoke (2013), and a minor role in the short web series Oh La La, Hollywood Speaks French! (2014) In 2015, he starred as Kieran Wilcox in the MTV horror series Scream. In 2018, Serafini guest starred as Josh in the web television series Impulse, and starred as Terry in the independent comedy film Summer Days, Summer Nights. In 2023, he starred as Henry Van Horne in the independent action-thriller Hidden Strike alongside John Cena and Jackie Chan.